In vitro antifungal activity of naftifine: (SN 105-843 GEL) against dermatophytes.

Antifungal activity of naftifinc (SN 105-843 gel) a napthyle alkyleamine derivative, was measured in vitro against freshly isolated cultures of dermatophytie fungi. Using appropriate concentrations of naftifine, its antifungal activity was compared with the same concentrations of griseofulvin against Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton violaceum, Trichophyton tonsurans, Microsporum Canis and Epidermophyton floccosum. The results indicated that minimal inhibitory concentration (MIC) for naftifinc was 0.1 Ug/ml against Trichophyton rub-rum, Trichophyton violaceum and Trichophyton tonsurans, whereas for griseofulvin the MIC was 0.5 UG/ml. This showed that naftifinc was more effective in vitro than griseofulvin against these fungi. The MIC of naftifinc and griseofulvin was identical i.e. 0.1 Ug/ml against Trichophyton mentagrophytes, Microsporum canis and Epidermophyton floccosum. (JPMA 31:279, 1981).